Live Cell Imaging System for Protein-Protein Interactions: Multiplexing Fluorescence Lifetime Imaging: a rapid HCS system to study protein-protein interactions in live cells

Challenge: Studies of intracellular protein-protein interactions (PPI) is emerging as an important drug discovery tool. Since many relevant targets can only be affected by drugs candidates in living cells, specific screening methods are implemented using sophisticated microscopy systems. A way to measure these interactions in cellulo is through the implementation of Förster Resonance Energy Transfer (FRET) combined with fluorescence lifetime … Read More