{"id":4062,"date":"2023-08-29T15:38:00","date_gmt":"2023-08-29T19:38:00","guid":{"rendered":"https:\/\/cqdm.org\/?post_type=project&#038;p=4062"},"modified":"2024-08-29T15:46:09","modified_gmt":"2024-08-29T19:46:09","slug":"optimizing-kbtbd4-corest1-acting-compounds-for-tissue-rejuvenation","status":"publish","type":"project","link":"https:\/\/cqdm.org\/en\/achievement\/funded-projects\/optimizing-kbtbd4-corest1-acting-compounds-for-tissue-rejuvenation\/","title":{"rendered":"Optimizing KBTBD4-CoREST1 acting compounds for tissue rejuvenation"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"is-style-suptitle\"><strong>Principal Investigator:<\/strong><\/p>\n\n\n\n<p><strong><strong><strong>Guy Sauvageau<\/strong><\/strong><br><\/strong>UdeM<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"is-style-suptitle\"><strong>Co-investigators<\/strong><\/p>\n\n\n\n<p><strong><strong><strong>Anne Marinier<\/strong><\/strong><br><\/strong>RejuvenRx<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>Project of $3,505,425 over 3 years<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"is-style-checkmark wp-block-list\">\n<li><strong><strong><strong><strong><strong>Supported by CQDM through:<\/strong><\/strong><\/strong><\/strong><\/strong>\n<ul class=\"wp-block-list\">\n<li>Minist\u00e8re de l\u2019\u00c9conomie, de l\u2019Innovation et de l\u2019\u00c9nergie du Qu\u00e9bec (MEIE)<\/li>\n\n\n\n<li>Canadian Institutes of Health Research (CIHR)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong><strong><strong>And by a co-funding partner:<\/strong><\/strong><\/strong>\n<ul class=\"wp-block-list\">\n<li>RejuvenRx<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Challenge<\/strong><\/h2>\n\n\n\n<p>Stem cell aging is caused by several well described hallmarks, most notably changes of the \u201cepigenome\u201d, which represent transient or permanent additions of molecules to DNA and surrounding proteins that turn genes on and off. Clearance of dysfunctional proteins is also severely perturbed with aging as is energy production and utilisation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Solution<\/h2>\n\n\n\n<p>Dr. Sauvageau\u2019s team has recently identified a novel cell-signaling pathway which, when activated, reverses stem cell aging and has the potential not only to halt the progression of age-related diseases, but to cure them. Researchers have recently discovered and developed a molecule that activates this signaling pathway; however, this molecule is not bioavailable when taken orally. This is a major issue preventing its use in humans. The project involves developing derivatives of this molecule and proving its efficacy in animal models.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Achievements\/Impact<\/strong><\/h2>\n\n\n\n<p>This project will provide a better understanding of age-related diseases such as Alzheimer&#8217;s and Parkinson\u2019s and identify a potential therapeutic solution for them. This new therapy could increase quality of life and potentially cure the hundreds of thousands of Quebecers suffering from these diseases, while considerably reducing costs for the healthcare system. Several <em>ex vivo<\/em> studies have demonstrated that the therapy has the potential to revolutionize the management of several age-related diseases. However, developing bioavailable molecules is crucial to patient treatment. The project targets a signaling pathway that has only recently been discovered, positioning Quebec as a leader in this field.<\/p>\n","protected":false},"featured_media":3830,"template":"","project-category":[96],"class_list":["post-4062","project","type-project","status-publish","has-post-thumbnail","hentry","project-category-small-molecules"],"acf":[],"_links":{"self":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project\/4062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/types\/project"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/media\/3830"}],"wp:attachment":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/media?parent=4062"}],"wp:term":[{"taxonomy":"project-category","embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project-category?post=4062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}