{"id":3020,"date":"2022-01-15T19:28:08","date_gmt":"2022-01-16T00:28:08","guid":{"rendered":"https:\/\/cqdm.org\/en\/achievement\/funded-projects\/research-and-development-of-an-antimetastatic-peptide-conjugate-of-docetaxel-th1902-against-sortilin-positive-cancers\/"},"modified":"2024-09-03T09:22:07","modified_gmt":"2024-09-03T13:22:07","slug":"research-and-development-of-an-antimetastatic-peptide-conjugate-of-docetaxel-th1902-against-sortilin-positive-cancers","status":"publish","type":"project","link":"https:\/\/cqdm.org\/en\/achievement\/funded-projects\/research-and-development-of-an-antimetastatic-peptide-conjugate-of-docetaxel-th1902-against-sortilin-positive-cancers\/","title":{"rendered":"Research and development of an antimetastatic peptide conjugate of docetaxel (TH1902) against sortilin positive cancers"},"content":{"rendered":"\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"is-style-suptitle wp-block-paragraph\"><strong>Principal Investigator:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>Borhane Annabi<\/strong><br><\/strong>UQAM<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"is-style-suptitle wp-block-paragraph\"><strong>Co-investigators<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">N\/A<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Project of $1,590,000 over\u00a02,5 years<\/h2>\n\n\n\n<ul class=\"is-style-checkmark wp-block-list\">\n<li><strong><strong>Supported by CQDM through:<\/strong><\/strong> Minist\u00e8re de l\u2019\u00c9conomie, de l\u2019Innovation et de l\u2019\u00c9nergie du Qu\u00e9bec (MEIE)<\/li>\n\n\n\n<li><strong><strong>And by a co-funding partner:<\/strong><\/strong> \n<ul class=\"wp-block-list\">\n<li> Theratechnologies<\/li>\n\n\n\n<li>Quebec Breast Cancer Foundation<\/li>\n\n\n\n<li>Mitacs<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Challenge<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cancers with metastases are responsible for 90% of cancer deaths. Unfortunately, metastases often become refractory to treatment and although certain molecules are theoretically able to act on these tumors, their non-targeted administration greatly limits their effectiveness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Solution<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This project aims to validate the efficacy of the peptide-drug (TH1902) on secondary tumors by characterizing its mechanisms of action in\u00a0<em>vitro<\/em>\u00a0and\u00a0<em>in vivo<\/em>\u00a0models of cancer metastasis, and by analyzing its pharmacokinetics and stability in biological fluids. The research team will also verify that TH1902 is functional in several types of metastatic cancers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Expected Achievements \/Impacts<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Overall, the resulting data will support and better define future clinical trials in patients with sortilin-positive metastatic cancers and to further explore the potential combination of its compound with other therapeutic drugs. The identification of new treatment options for patients with overexpression of the sortilin receptor offers tremendous hope, particularly for tumors that are refractory to available anti-cancer treatments.<\/p>\n","protected":false},"featured_media":3823,"template":"","project-category":[97],"class_list":["post-3020","project","type-project","status-publish","has-post-thumbnail","hentry","project-category-biological-and-therapeutic"],"acf":[],"_links":{"self":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project\/3020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/types\/project"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/media\/3823"}],"wp:attachment":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/media?parent=3020"}],"wp:term":[{"taxonomy":"project-category","embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/project-category?post=3020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}