{"id":2262,"date":"2023-07-18T19:40:09","date_gmt":"2023-07-18T23:40:09","guid":{"rendered":"https:\/\/cqdm.org\/en\/news-and-events\/development-and-evaluation-of-a-multimodal-approach-to-predict-lung-cancer-risk-and-determine-egfr-mutation-profile-in-a-lung-cancer-screening-population\/"},"modified":"2024-09-25T16:25:48","modified_gmt":"2024-09-25T20:25:48","slug":"development-and-evaluation-of-a-multimodal-approach-to-predict-lung-cancer-risk-and-determine-egfr-mutation-profile-in-a-lung-cancer-screening-population","status":"publish","type":"post","link":"https:\/\/cqdm.org\/en\/news-and-events\/development-and-evaluation-of-a-multimodal-approach-to-predict-lung-cancer-risk-and-determine-egfr-mutation-profile-in-a-lung-cancer-screening-population\/","title":{"rendered":"Development and Evaluation of a Multimodal Approach to Predict Lung Cancer Risk and Determine EGFR Mutation Profile in a Lung Cancer Screening Population"},"content":{"rendered":"\n

Challenge:<\/strong> Lung\u00a0cancer is the most lethal cancer in industrialized countries, with\u00a0different studies showing that its high mortality can be reduced through an early diagnosis. Implementation of a lung cancer screening program for patients at high risk of developing the disease has been recently recommended by the Quebec National Institute of Excellence in Health and Social Services (INESSS). This program targets about 380,000 individuals in the province of Quebec. Potential harms associated with the implementation of a lung cancer screening program include false-positive results leading to unnecessary tests and invasive procedures. The additional clinical resources (access to physician, radiology, pathology) to obtain a reasonable balance of benefits over harms represent a significant challenge in the context of a public health system.<\/p>\n\n\n\n

Solution:<\/strong> The\u00a0project responses to this new clinical reality with a focus to ensure the benefits of lung cancer screening in reducing lung cancer mortality\u00a0and\u00a0at the same time\u00a0alleviate\u00a0the extra pressure on the health care system. More specifically, in this research proposal,\u00a0the team\u00a0aims\u00a0to improve the efficiency of lung cancer screening program by integrating genetic score, metabolic profile and radiomics\u00a0(i.e., high-throughput analysis of medical imaging)\u00a0by artificial intelligence\u00a0to better select the patients that should undergo additional imaging and invasive procedures such as lung biopsy and surgery.\u00a0\u00a0The\u00a0work\u202fwill be\u00a0based on data and samples from IUCPQ-UL\u2019s biobank and the Lung\u00a0cancer screening demonstration\u00a0project.<\/p>\n\n\n\n

Expected achievements\/Impact :<\/strong> This\u00a0project\u00a0will develop and assess the clinical performance of predictive biomarkers to complement and enhance the outcomes of a lung cancer screening program.\u00a0It\u00a0will be the first time that a multimodal predictive model\u00a0that integrates radiomics, liquid biopsy and genetic score\u00a0to improve\u00a0patient\u00a0management and\u00a0reduce costs will be developed and applied in the context of a screening cohort for this disease.\u00a0By working\u00a0with\u00a0private biotech companies well established in the province\u00a0of Quebec and worldwide leaders in their field, it\u00a0will\u00a0be possible to rapidly scale up\u00a0the\u00a0technologies to be applied in our population.<\/p>\n\n\n\n

Principal Investigators:<\/strong>
Philippe Joubert\u00a0<\/strong>
Yohan Boss\u00e9<\/strong>
IUCPQ \u2013 Universit\u00e9 Laval<\/td><\/tr>
Co-Investigators:<\/strong>
Venkata Manem<\/strong>
Simon Martel\u00a0<\/strong>
Gabriella Albert\u00a0<\/strong>
Philippe Despr\u00e9s<\/strong>
IUCPQ\u00a0\u2013 Universit\u00e9 Laval
Jean-Fran\u00e7ois Haince<\/strong>
BioMark\u00a0Diagnostic Solutions
Ryan Demers<\/strong>\u00a0\u00a0
AstraZeneca<\/td><\/tr>
Ongoing <\/strong><\/strong><\/strong><\/strong><\/strong><\/strong>Project<\/strong><\/td><\/tr>
$3,397,255\u00a0\/ 3 years<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/td><\/tr>
Supported by CQDM through:<\/strong>
– Pfizer Canada
– MEIE<\/td><\/tr>
And by co-funding partners:<\/strong>
– Fondation\u00a0IUCPQ
– BioMark Diagnostic Solutions
– AstraZeneca<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"

Challenge: Lung\u00a0cancer is the most lethal cancer in industrialized countries, with\u00a0different studies showing that its high mortality can be reduced through an early diagnosis. Implementation of a lung cancer screening program for patients at high risk of developing the disease has been recently recommended by the Quebec National Institute of Excellence in Health and Social…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2262","post","type-post","status-publish","format-standard","hentry","category-our-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/posts\/2262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/comments?post=2262"}],"version-history":[{"count":1,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/posts\/2262\/revisions"}],"predecessor-version":[{"id":4798,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/posts\/2262\/revisions\/4798"}],"wp:attachment":[{"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/media?parent=2262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/categories?post=2262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cqdm.org\/en\/wp-json\/wp\/v2\/tags?post=2262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}