MORAG PARK

Integrating Tumour-Microenvironment Biomarkers to Improve Diagnostic and Facilitate Targeted Breast Cancer Therapy

Challenge: It has become increasingly clear that breast cancer progression, response to therapy and ultimately disease outcomes are determined not only by features of the tumour itself, but also by characteristics of, and interactions with the surrounding tissue, or stroma. Currently, stromal information is not used for patient stratification in clinical setting, trial design or retrospective analyses of drug efficacy … Read More

MORAG PARK

Development of a high throughput bioprinted 3D human tumor microenvironment assay that recreates immune “hot” and “cold” tumors

Challenge: Solid tumor growth is regulated by complex interactions of tumor cells with an assortment of adjacent non-malignant cells collectively referred to as the tumor microenvironment (TME). In “triple-negative breast cancer” (TNBC), which represents 15 to 20 % of all breast cancers, tumors can be characterized as “immune hot” or “immune cold” with respect to the level of infiltration of … Read More

FERNAND GOBEIL JR

Towards the Development of a New Class of Anti-GPCR Antibodies for the Treatment of Aggressive Cancers

Challenge: G protein-coupled receptors (GPCRs) represent attractive biomarkers and therapeutic target classes in cancer research because their aberrant expression and activity are closely correlated with different stages of tumour initiation and progression. The development of small molecule anticancer drugs targeting GPCRs has so far proven to be quite challenging. Thus, there remains a need to identify new approaches to treating … Read More

*MATHIEU PERRÉE

Integrating Functional and Genomic Profiling for Optimal Combination Therapies for Cancer Patients

Challenge: In recent years, a growing number of cancer patients have been treated with therapies targeting specific genetic alterations present in their tumors. Generally, this is done in combination with traditional chemotherapeutic agents that represent the standard of care. However, a systematic analysis to identify the most appropriate combination of chemo and targeted therapy to which a patient will favorably … Read More

*JEFF WRANA

A Novel Platform Combining Transcriptomics and Interaction Proteomics to Better Define Personalized Medicine in Cancer

Challenge: In the last decade, cancer genomics has shown that not all patient tumours are identical, and conversely that they will not respond similarly to anticancer agents. The key, therefore, is personalized (or precision) medicine whereby specific drugs will be given to a patient carrying a gene that will make their tumours sensitive to such drugs. However, the identification of genes … Read More

*YVES ST-PIERRE

Dimer Interference: A novel Approach to Develop Galectin-7-Specific Inhibitors to treat Triple-Negative Breast Cancer

Challenge: Galectins are a family of lectin proteins implicated in tumor progression and immune evasion. When produced in excess by cancer cells, galectins can form homodimers and bind glycans on the surface of T cells. This suppresses the local and systemic immune response in patients, helping tumors to escape immune surveillance and limiting the efficacy of immuno-oncology treatments. To date, … Read More

*ANNE-MARIE MES-MASSON

Circumventing the need for predictive biomarkers in personalized ovarian cancer therapies: empirical chemosensitivity testing using a microfluidics-based multiplex platform

Challenge: Ovarian cancer is a leading cause of cancer death in women. Only a fraction of women diagnosed with ovarian cancer will respond to current therapies. In order to better tailor treatment to each patient, personalized medicine has turned to biomarkers that statistically evaluate the chances of a drug to be effective for a patient. Nevertheless, there is currently no … Read More

*EL BACHIR AFFAR

Facilitating Anti-Cancer Drug Discovery with Selective Inhibitors to Modulate the Protein Ubiquitination Process

Challenge: Human cells eliminate non-functional proteins using a sophisticated degradation pathway named the ubiquitin proteasome system (UPS), in which UPS enzymes attach a small protein called ubiquitin to damaged target proteins to tag them for degradation. However, abnormalities in protein degradation are frequently observed in many diseases, including cancer where aberrant control of protein degradation can lead to uncontrolled cell … Read More