NATHAN YOGANATHAN

Developing new Alzheimer’s therapeutics using novel blood brain barrier carrier technology

  Competition: Focus on Brain 2014 Funding: $2,413,133 / 3 years Beginning: May 2015 Challenge: Of the top 10 most fatal illnesses in the world, Alzheimer’s disease is the only one for which there is currently no disease-modifying therapy available. Alzheimer’s disease becomes progressively more prevalent as people age, rising from over 11% of the population 65 and older to … Read More

*JANUSZ PAWLISZYN

In-vivo Solid Phase Microextraction Integrated with Mass Spectrometry Platform for Untargeted and Targeted Investigation of the Brain

Challenge: One of the major challenges currently faced by the pharmaceutical industry is the development of alternative approaches that allow the gathering of maximum information using a minimum number of animals. With regard to analytical instruments, mass spectrometers offer increasingly sensitive and quantitative determination of biological molecules. However, collected biological samples, especially tissues, require efficient sample preparation prior to mass … Read More

*THÉRÈSE DI PAOLO

Catecholamine-Regulated Protein 40 (CRP40) as a New Candidate Biomarker for Early Diagnosis of Parkinson’s Disease

Challenge: Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder afflicting 1 to 2% of the population over 65 years of age and for which there is neither a reliable diagnostic test nor cure. Since catecholamine-regulated protein 40 (CRP40) may be involved in regulation of dopamine in the brain, it represents a potential biomarker for early diagnosis of Parkinson’s disease. … Read More

XIAO-YAN WEN

Development of automated zebrafish high throughput screening technology platforms to accelerate screening of small molecules in disease models of protein misfolding and aggregation

  Competition: Québec / Ontario Program 2013 Funding: $910,000 / 3 years Beginning: September 2014 This project is a groundbreaking collaboration between researchers at St. Michael’s Hospital (SMH) and Treventis Corporation (both in Toronto), as well as the University of Montreal. Dr. Xiao-Yan Wen (SMH) and Dr. Pierre Drapeau (University of Montreal) are experts in zebrafish models of disease. The zebrafish is … Read More

*MICHEL MAZIADE

Non-Invasive Diagnostic Test Using Electroretinography for Profiling Patients with Schizophrenia and Bipolar Disorders

Challenge: Psychiatric disorders such as schizophrenia, bipolar disorder and major depression affect 25 million of individuals in North America. Early identification of risk factors for people with genetic predispositions remains the most promising avenue for improving the treatments for these diseases. However, there are multiple subgroups of patients within a specific disease whose condition is mediated by different molecular pathologies, … Read More

*SÉBASTIEN BLAIS-OUELLETTE

Innovative Optical Imaging and Bio-Simulation Platforms to Accelerate Central Nervous System Drug Discovery

Challenge: The development of efficient drugs targeting central nervous system (CNS) diseases remains a challenge, especially because of a lack of effective methods for studying processes occurring at the synaptic level. Protein interactions at the synapse are known to be modified under pathological conditions and to induce important changes in cellular function. Despite great advances in imaging, it remains difficult … Read More

DON VAN MEYEL

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

  Competition: Focus on Brain 2014 Funding: $1,416,375 / 3 years Beginning: May 2015 Challenge: In the human brain and retina, the chemical glutamate is a very important messenger that carries information from one neuron to another. The levels of glutamate transmitted between neurons must be tightly controlled: too high and neurons die, too low and information is not communicated … Read More

ROB HUTCHINSON

La meilleure plateforme d’administration de médicament traversant la barrière hémato-encéphalique

  Competition: Focus on Brain 2014 Funding: $2,573,875 / 3 years Beginning: May 2015 Challenge: The blood-brain barrier (BBB) is a tightly woven layer of vascular cells in the brain that prevents harmful molecules from the circulation, viruses and toxins, from entering the brain. To allow entry of nutrients into the brain, the BBB employs molecular transporters that shuttle nutrients … Read More

*BARRY BEDELL

Alzheimer’s Disease Mouse Model Characterization: Correlation Between MRI and ex vivo Immunohistochemistry

Challenge: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting elderly people. There is currently no early diagnostic method available and there is no effective treatment. Better characterization of new animal models is therefore essential to enable the discovery of new therapeutics for AD. Solution: To maximize the information obtained from MRI and PET imaging studies of animal models for … Read More

JEAN-PAUL SOUCY

Detection of Alzheimer’s Disease in the Prodromal Stage from Non-Invasive Hyperspectral Retinal Images

Challenge: Alzheimer’s disease (AD) affects millions of people worldwide, causing an irreversible and debilitating loss of neuro-cognitive functions, with no cure currently available. At the moment, AD diagnosis can be confirmed post-mortem or through complex in vivo imaging approaches (Positron Emission Tomography or PET scanner) by observing two AD hallmarks in the brain, the deposition of β-amyloid (Aβ) plaques and … Read More