*PATRICK VERMETTE

Development of a New Matrix for Pancreatic Islets Culture and its Validation in a Bioartificial Pancreas

Challenge: Islet transplantation is an efficient therapy to reverse type 1 diabetes. However, the long-term function of the graft is not ensured, and the problem of autoimmunity remains. An interesting alternative consists of a bioartificial pancreas in which islets are encapsulated. However, the islet environment within such a pancreas still needs to be improved to better preserve islet survival and function. … Read More

PAVEL HAMET

Genetic testing to guide therapeutic decision in diabetic patients of various ethnic backgrounds

Challenge: Type 2 diabetes (T2D) is the leading cause of cardiovascular and renal diseases. Although many treatments are available, they only partially reduce the risk of serious complications in diabetic patients. As a first step towards reducing diabetes-related morbidity and mortality, the team has developed a Polygenic Risk Score (PRS) in T2D Caucasian patients that combines with sex, age of … Read More

*JOCELYN DUPUIS

PulmoBind: A New Non-Invasive Marker for the Early Diagnosis of Patients with Pulmonary Hypertension

Challenge: Pulmonary hypertension (PH) is a condition associated with loss of blood vessels in the lungs leading to a gradual increase in shortness of breath and substantial disability and mortality. The development of effective drugs is impeded by the lack of non-invasive tests to detect the disease at an early stage and to follow its progression. Solution: The goal of … Read More

*EUSTACHE PARAMITHIOTIS

Biomarkers Discovery in Diabetes: New Biomarkers for Measurement of Early Stage Diabetes Disease and for Prediction of Response to Therapy

Challenge: Pancreatic islets play a critical role in diabetes development with about 50% of their function being lost by the time pre-diabetic patients are diagnosed. Levels of pancreatic ß-cells are currently approximated through measurements of blood glucose, C-peptide, and insulin levels. There is therefore an urgent need to develop biomarkers that more accurately monitor the physiological status of pancreatic ß-cells, … Read More

PAVEL HAMET

A genetic test to predict diabetic nephropathy in Type 2 diabetes patients

Competition: SynergiQc 2017 Funding: $683,665 / 2 years Beginning: July 2017 Challenge: Occurrence of type 2 diabetes (T2D) is increasing worldwide, and particularly among younger subjects who are more susceptible to renal complications that can lead to renal failure. Such diabetic nephropathy (DN) is present in about 40% of T2D patients. Treatments exist to control renal damage due to T2D … Read More