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QUO2 MRI: Quantitative Measurement of Metabolic and Vascular Anomalies in the Brain of Alzheimer’s Disease Patients

Challenge: The underlying causes of Alzheimer’s disease (AD) remain poorly understood, and only few dynamic biomarkers are available to monitor responses for experimental therapies. Neuroimaging methods such as structural magnetic resonance imaging (MRI) can detect brain atrophy, but slow changes during disease progression cannot be measured during the timeframe of clinical trials, while functional MRI (fMRI) methods are not yet … Read More

Tuesday October 1st, 2019


Selectomics to monitor and predict the emergence of resistance to antibiotics by using the human microbiome

Challenge: Antibiotics represent some of the most important drugs available to modern medicine because they can often treat bacterial infections that would otherwise pose a serious health threat. However, there is currently a lack of new antibiotic development by the industry due to reduced economic incentives as well as challenging scientific and regulatory requirements. To exacerbate the problem, bacteria targeted … Read More

Thursday September 26th, 2019


Computational and machine learning approaches to improve design and screening of peptides in drug discovery

Challenge: Protein-protein interactions (PPI) are well recognized as promising therapeutic targets. Although interfering peptides capable of inhibiting PPIs are receiving increased attention, the identification of those that possess high biological activity is very challenging due to their enormous diversity. There is thus a need to use bioinformatics and machine learning to effectively predict if a compound could be efficacious, which … Read More


Integrating Tumour-Microenvironment Biomarkers to Improve Diagnostic and Facilitate Targeted Breast Cancer Therapy

Challenge: It has become increasingly clear that breast cancer progression, response to therapy and ultimately disease outcomes are determined not only by features of the tumour itself, but also by characteristics of, and interactions with the surrounding tissue, or stroma. Currently, stromal information is not used for patient stratification in clinical setting, trial design or retrospective analyses of drug efficacy … Read More

Thursday August 22nd, 2019


Magnetically Guided Bacteria to Specifically Deliver Anti-Cancer Agents to Colorectal Cancer Sites

Challenge: Many cancers are treated with cocktails of chemotherapeutic drugs designed to prevent growth and spread of cancerous cells. Chemotherapy damages healthy cells, causing undesired side effects such as myelosuppression and cardiotoxicity. Localized drug therapy, if appropriately delivered could have a major impact on quality of life and treatment efficacy. Solution: The lead investigator has pioneered a revolutionary drug delivery … Read More

Wednesday September 12th, 2018


New GPCR-Specific Biosensor Technology to Monitor Cellular Events Associated with Drugs Efficacy and Side Effects

Challenge: G protein-coupled receptors (GPCRs) form the largest family of cell surface receptors involved in signal transduction of many hormones and transmitters. It follows that drugs targeting GPCRs represent close to 40% of all drugs on the market today. Recent discoveries regarding their function and mechanism of action help pave the way for the development of more selective therapeutics for … Read More

Tuesday September 11th, 2018


Non-Invasive Diagnostic Test Using Electroretinography for Profiling Patients with Schizophrenia and Bipolar Disorders

Challenge: Psychiatric disorders such as schizophrenia, bipolar disorder and major depression affect 25 million of individuals in North America. Early identification of risk factors for people with genetic predispositions remains the most promising avenue for improving the treatments for these diseases. However, there are multiple subgroups of patients within a specific disease whose condition is mediated by different molecular pathologies, … Read More

Monday September 10th, 2018


PulmoBind: A New Non-Invasive Marker for the Early Diagnosis of Patients with Pulmonary Hypertension

Challenge: Pulmonary hypertension (PH) is a condition associated with loss of blood vessels in the lungs leading to a gradual increase in shortness of breath and substantial disability and mortality. The development of effective drugs is impeded by the lack of non-invasive tests to detect the disease at an early stage and to follow its progression. Solution: The goal of … Read More

Friday September 7th, 2018


VLPExpress®: Novel high-throughput discovery platform to accelerate the development of new vaccines based on Virus-Like Particles

Challenge: Despite the enormous benefits that traditional vaccines have brought to human health in the last century, preventable diseases continue to claim millions of lives each year. New vaccine technologies that offer speed and versatility in production would have significant impact. The emergence of technologies based on Virus-Like Particles (VLPs) has paved the way for a new generation of vaccines … Read More


A novel phage-based screening technology for antiviral

Challenge: Infection with herpes viruses is associated with several immunodeficient human diseases including the development of cancers. Patients receiving organ transplants are particularly sensitive to such infections. These patients are treated with antiviral agents; however, approved drugs are often associated with severe side effects and the development of resistance can compromise therapy. There is thus an urgent need to discover … Read More


Biomarkers Discovery in Diabetes: New Biomarkers for Measurement of Early Stage Diabetes Disease and for Prediction of Response to Therapy

Challenge: Pancreatic islets play a critical role in diabetes development with about 50% of their function being lost by the time pre-diabetic patients are diagnosed. Levels of pancreatic ß-cells are currently approximated through measurements of blood glucose, C-peptide, and insulin levels. There is therefore an urgent need to develop biomarkers that more accurately monitor the physiological status of pancreatic ß-cells, … Read More

Monday July 9th, 2018

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