*ANNE-MARIE MES-MASSON

Circumventing the need for predictive biomarkers in personalized ovarian cancer therapies: empirical chemosensitivity testing using a microfluidics-based multiplex platform

 

Competition: EXPLORE Program 2012
Funding: $300,000 / 2 years
Beginning: September 2014

(COMPLETED PROJECT)

Ovarian cancer is a leading cause of cancer deaths in women. Only a portion of women diagnosed with this cancer will respond to conventional drugs, and alternative therapies only work in some cases. In order to better tailor treatment, personalized medicine has turned to ‘markers’ that statistically evaluate the chances of a drug being effective. Here we propose a completely different approach, where we will directly test in the tumor cells themselves their ability to respond to multiple drugs. While this approach has been tried before, it has largely failed because it didn’t take into account the specific features of the tumor tissue, wasn’t economical enough, and couldn’t be performed sufficiently rapidly to influence clinical decision-making. By using a miniaturized system, coupled to the novel model systems we have developed over the last several years, we propose to rapidly test either complex three dimensional cell structures, or even miniscule pieces of tumor tissue, for their response to therapy. The fact that we can in parallel test different samplings of any given tumor, as well a rapid and real-time readout of whether the tumor cells are dying, will provide us with a way we can efficiently and cost-effectively determine whether a specific treatment will be of benefit to the patient, thus improving outcomes and managing health costs.

Anne-Marie
Mes-Masson

Université de Montréal

Co-Investigators

Frédéric Lesage and Thomas Gervais
École Polytechnique de Montréal

Mentors

Aidan Gilmartin
Investigator/Manager,
GSK

Bonnie Howell
Senior Scientific Director,
Merck Research Laboratories

Jonathan A. Lee
Senior Research Advisor,
Eli Lilly and Co.

David J. Shields
Principal Scientist, Oncology Research Unit,
Pfizer