Development of novel biologic inhibitors of Semaphorin3A for the treatment of retinal vascular diseases.
Challenge: Diabetic retinopathy and age-related macular degeneration are the leading causes of blindness in working age and elderly populations. While anti-VEGFs revolutionized treatment of retinal vasculopathies, currently available drugs can cause neuronal degeneration. Besides, over 40% of patients respond poorly to these treatments, leaving patients with no alternative, ultimately leading them to blindness. There is […]