Funded Projects
CQDM/Alsace BioValley/Lyonbiopôle Joint Program
2011 Funded Projects
Michel Bouvier |
Monitoring the signaling pathways of GPCRs in living animals This project aims to generate genetically modified mice that will allow direct observation of the action of molecules on the G protein-coupled receptors using an innovative microscopic imaging technique. These new animal models will permit the visualization of the effects of target molecules at the cellular and molecular level hence facilitating the development of drugs with greater therapeutic efficacy and less undesirable side effects. |
Sébastien Blais-Ouellette |
Optical imaging and biosimulation platforms to accelerate CNS drug discovery Investigators The synergy between the expertise of the collaborators will lead to the development of two innovative platforms to facilitate drug discovery and development: 1) an imaging platform used to study the effect of drugs on the dynamics of neuronal proteins and 2) a biosimulation platform for integrating signaling mechanisms at the synapse level to model and predict the effect of candidate drugs on neuronal functions. |
2010 Funded Project
Daniel Chelsky |
Identification of new biomarkers for neuroendocrine cancers This project will investigate the mechanisms resulting in hypersecretion by neuroendocrine tumors, as well as identify the changes to the proteins secreted by such tumors. Identified candidate targets for modulation of hypersecretion could generate improved therapies. Furthermore, the resulting identification of candidate secretory protein biomarkers could become the basis of better diagnostic and prognostic markers. |
